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Epigenetics

Overview

Department of Epigenetics

Virtually all 37.2 trillion cells in our bodies have the same DNA, the spiraling molecule that contains the genetic instructions required to make us who we are. But if every cell works from the same playbook, how and why does the human body have so many different types of cells? Why do some become skin cells while others become muscle cells, heart cells or brain cells?

The answer is epigenetics — a complex set of processes that determine when and to what extent certain genetic instructions are carried out. Epigenetic processes are vital for healthy cellular function and, when things go awry, they can play major roles in disease.

Scientists in VAI’s Department of Epigenetics seek to understand how epigenetic changes may either protect us from or predispose us to complex diseases such as cancer, Parkinson’s and metabolic disorders. By investigating the epigenetic processes that fine-tune DNA, our scientists aim to pinpoint the origins of these complex diseases and determine how they are impacted by our past, present and future.

Our Faculty

J. Andrew Pospisilik, Ph.D.

Chair and Professor, Department of Epigenetics

Epigenetic Origins of Heterogeneity and Disease

Peter A. Jones, Ph.D., D.Sc. (hon)

VAI Chief Scientific Officer

Epigenetic Therapies

Scott Rothbart, Ph.D.

Associate Professor, Department of Epigenetics

Chromatin and Epigenetics Regulation

Steven J. Triezenberg

President and Dean, Van Andel Institute Graduate School

Stephen Baylin, M.D.

Co-leader, Van Andel Institute–Stand Up To Cancer Epigenetics Dream Team

VAI–SU2C Epigenetics Dream Team

Department Staff

Recent Publications

Our Impact

We're raising thousands to save millions

We’re turning hope into action for the millions of people around the world affected by diseases like cancer and Parkinson’s. Find out how you can help us make a difference.

  • 171 studies published from Nov. 1, 2020 to Oct. 1, 2021
  • 68 studies in high-impact journals from Nov. 1, 2020-Oct. 1, 2021
  • 41 clinical trials launched
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